MLK3, active Human Recombinant Kinase Protein
10 µg of active MLK3. N-terminal GST-tagged, recombinant, human MLK3 amino acids 1-468.
No items found.
Biological information
Background
MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Target class
Kinase
Family
Accession number
NM_002419.2
Target Name
MLK3, active Human Recombinant Kinase Protein
Target Alias
Mitogen-Activated Protein Kinase Kinase Kinase 11
MEKK11
Src-Homology 3 Domain-Containing Proline-Rich Kinase
Mixed Lineage Kinase 3
SH3 Domain-Containing Proline-Rich Kinase
Protein-Tyrosine Kinase PTK1
EC 2.7.11
Origin
Human
Theori. MW
79 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 90% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using glutathione agarose.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Compound name
Kinase
Catalog number
16-039
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Target class
Kinase
Family
Subfamily
Protein Name
MLK3
Protein Alias
Mitogen-Activated Protein Kinase Kinase Kinase 11
MEKK11
Src-Homology 3 Domain-Containing Proline-Rich Kinase
Mixed Lineage Kinase 3
SH3 Domain-Containing Proline-Rich Kinase
Protein-Tyrosine Kinase PTK1
EC 2.7.11
Accession Number
NM_002419.2
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C.
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Target class
Kinase
Family
Accession Number
NM_002419.2
Target Name
MLK3
Target Alias
Mitogen-Activated Protein Kinase Kinase Kinase 11
MEKK11
Src-Homology 3 Domain-Containing Proline-Rich Kinase
Mixed Lineage Kinase 3
SH3 Domain-Containing Proline-Rich Kinase
Protein-Tyrosine Kinase PTK1
EC 2.7.11
Origin
Human
Theoretical MW
Affinity Tag
GST
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 90% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using glutathione agarose.
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Biological Information
Background
MLK3 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Target class
Kinase
Family
Accession Number
NM_002419.2
Target Name
MLK3
Target Alias
Mitogen-Activated Protein Kinase Kinase Kinase 11
MEKK11
Src-Homology 3 Domain-Containing Proline-Rich Kinase
Mixed Lineage Kinase 3
SH3 Domain-Containing Proline-Rich Kinase
Protein-Tyrosine Kinase PTK1
EC 2.7.11
Origin
Human
Theoretical MW
Affinity Tag
GST
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 90% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using glutathione agarose.
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only