JAK3, active Human Recombinant Kinase Protein
N-terminal 6His-tagged recombinant, human JAK3 amino acids 781-end.
No items found.
Biological information
Background
Janus kinase 3 (JAK3) is a nonreceptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoeiesis and protection from bain damage following hypoxia. Inhibition may also adversely effect diabetes.
GenBank AF513860
Target class
Kinase
Family
TK
Accession number
NM_000215.2
Target Name
JAK3, active Human Recombinant Kinase Protein
Target Alias
JAK3, JAKL, LJAK, JAK3_HUMAN, L-JAK, JAK-3
Origin
Human
Theori. MW
39.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Janus kinase 3 (JAK3) is a nonreceptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoeiesis and protection from bain damage following hypoxia. Inhibition may also adversely effect diabetes.
GenBank AF513860
Compound name
Kinase
Catalog number
14-629
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
Janus kinase 3 (JAK3) is a nonreceptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoeiesis and protection from bain damage following hypoxia. Inhibition may also adversely effect diabetes.
GenBank AF513860
Target class
Kinase
Family
TK
Subfamily
Protein Name
JAK3
Protein Alias
JAK3, JAKL, LJAK, JAK3_HUMAN, L-JAK, JAK-3
Accession Number
NM_000215.2
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
Janus kinase 3 (JAK3) is a nonreceptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoeiesis and protection from bain damage following hypoxia. Inhibition may also adversely effect diabetes.
GenBank AF513860
Target class
Kinase
Family
TK
Accession Number
NM_000215.2
Target Name
JAK3
Target Alias
JAK3, JAKL, LJAK, JAK3_HUMAN, L-JAK, JAK-3
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
Janus kinase 3 (JAK3) is a nonreceptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoeiesis and protection from bain damage following hypoxia. Inhibition may also adversely effect diabetes.
GenBank AF513860
Target class
Kinase
Family
TK
Accession Number
NM_000215.2
Target Name
JAK3
Target Alias
JAK3, JAKL, LJAK, JAK3_HUMAN, L-JAK, JAK-3
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only