IRAK1, active Human Recombinant Kinase Protein
N-terminal 6His-tagged recombinant, human IRAK1 amino acids 194-end.
No items found.
Biological information
Background
IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-κB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-κB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis.
GenBank NM_001569
Target class
Kinase
Family
TKL
Accession number
NM_001025242.1; NM_001025243.1; NM_001569.3
Target Name
IRAK1, active Human Recombinant Kinase Protein
Target Alias
IRAK1, IRAK, IRAK-1, pelle
Origin
Human
Theori. MW
59.7 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-κB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-κB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis.
GenBank NM_001569
Compound name
Kinase
Catalog number
14-684
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-κB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-κB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis.
GenBank NM_001569
Target class
Kinase
Family
TKL
Subfamily
Protein Name
IRAK1
Protein Alias
IRAK1, IRAK, IRAK-1, pelle
Accession Number
NM_001025242.1; NM_001025243.1; NM_001569.3
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-κB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-κB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis.
GenBank NM_001569
Target class
Kinase
Family
TKL
Accession Number
NM_001025242.1; NM_001025243.1; NM_001569.3
Target Name
IRAK1
Target Alias
IRAK1, IRAK, IRAK-1, pelle
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-κB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-κB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis.
GenBank NM_001569
Target class
Kinase
Family
TKL
Accession Number
NM_001025242.1; NM_001025243.1; NM_001569.3
Target Name
IRAK1
Target Alias
IRAK1, IRAK, IRAK-1, pelle
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only