Fms (Y969C), active Human Recombinant Kinase Protein
N-terminal 6His-tagged recombinant, human Fms amino acids 538-end containing the mutation Y969C.
No items found.
Biological information
Background
CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series.
GenBank U63963
Target class
Kinase
Family
TK
Accession number
U63963
Target Name
Fms (Y969C), active Human Recombinant Kinase Protein
Target Alias
CSF1R, FIM2, CSF-1-R, C-FMS, CSFR, c-fms, CD115, FMS
Origin
Human
Theori. MW
50.2 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series.
GenBank U63963
Compound name
Kinase
Catalog number
14-820
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series.
GenBank U63963
Target class
Kinase
Family
TK
Subfamily
Protein Name
Fms
Protein Alias
CSF1R, FIM2, CSF-1-R, C-FMS, CSFR, c-fms, CD115, FMS
Accession Number
U63963
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series.
GenBank U63963
Target class
Kinase
Family
TK
Accession Number
U63963
Target Name
Fms
Target Alias
CSF1R, FIM2, CSF-1-R, C-FMS, CSFR, c-fms, CD115, FMS
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series.
GenBank U63963
Target class
Kinase
Family
TK
Accession Number
U63963
Target Name
Fms
Target Alias
CSF1R, FIM2, CSF-1-R, C-FMS, CSFR, c-fms, CD115, FMS
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only