ErbB4, active Human Recombinant Kinase Protein
N-terminal 6His-tagged recombinant, human ErbB4 amino acids 706-991.
No items found.
Biological information
Background
The ERBB family of receptor tyrosine kinases, namely the EGF receptor (EGFR), ERBB2/HER2/Neu, ERBB3, and ERBB4, regulate cellular proliferation, differentiation, and programmed cell death in a growth factor–dependent manner. ERBBs mediate signaling by a large number of growth factors that are structurally related to EGF such as transforming growth factor-a or amphiregulin.
GenBank NM_005235
Target class
Kinase
Family
TK
Accession number
NM_001005915.1; NM_001982.2
Target Name
ErbB4, active Human Recombinant Kinase Protein
Target Alias
ERBB4, HER4
Origin
Human
Theori. MW
36.1 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
The ERBB family of receptor tyrosine kinases, namely the EGF receptor (EGFR), ERBB2/HER2/Neu, ERBB3, and ERBB4, regulate cellular proliferation, differentiation, and programmed cell death in a growth factor–dependent manner. ERBBs mediate signaling by a large number of growth factors that are structurally related to EGF such as transforming growth factor-a or amphiregulin.
GenBank NM_005235
Compound name
Kinase
Catalog number
14-569
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
The ERBB family of receptor tyrosine kinases, namely the EGF receptor (EGFR), ERBB2/HER2/Neu, ERBB3, and ERBB4, regulate cellular proliferation, differentiation, and programmed cell death in a growth factor–dependent manner. ERBBs mediate signaling by a large number of growth factors that are structurally related to EGF such as transforming growth factor-a or amphiregulin.
GenBank NM_005235
Target class
Kinase
Family
TK
Subfamily
Protein Name
ErbB4
Protein Alias
ERBB4, HER4
Accession Number
NM_001005915.1; NM_001982.2
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
The ERBB family of receptor tyrosine kinases, namely the EGF receptor (EGFR), ERBB2/HER2/Neu, ERBB3, and ERBB4, regulate cellular proliferation, differentiation, and programmed cell death in a growth factor–dependent manner. ERBBs mediate signaling by a large number of growth factors that are structurally related to EGF such as transforming growth factor-a or amphiregulin.
GenBank NM_005235
Target class
Kinase
Family
TK
Accession Number
NM_001005915.1; NM_001982.2
Target Name
ErbB4
Target Alias
ERBB4, HER4
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
The ERBB family of receptor tyrosine kinases, namely the EGF receptor (EGFR), ERBB2/HER2/Neu, ERBB3, and ERBB4, regulate cellular proliferation, differentiation, and programmed cell death in a growth factor–dependent manner. ERBBs mediate signaling by a large number of growth factors that are structurally related to EGF such as transforming growth factor-a or amphiregulin.
GenBank NM_005235
Target class
Kinase
Family
TK
Accession Number
NM_001005915.1; NM_001982.2
Target Name
ErbB4
Target Alias
ERBB4, HER4
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only