CK1α, active Human Recombinant Kinase Protein
10 µg of active CK1α. N-terminal FLAG-tagged, N-terminal 6His-tagged, recombinant, human CK1 alpha, full length.
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Biological information
Background
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. CKIa enables protein serine/threonine kinase activity. CK1a is also involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]
Target class
Kinase
Family
Accession number
L37042.1
Target Name
CK1α, active Human Recombinant Kinase Protein
Target Alias
CSNK1A1Casein Kinase 1 Alpha 1CKIalphaHLCDGP1PRO2975HEL-S-77p
Origin
Human
Theori. MW
42 kDa
Affinity tag
FLAG, 6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
67% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using immuno-affinity chromatography and immobilized metal affinity
chromatography.
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. CKIa enables protein serine/threonine kinase activity. CK1a is also involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]
Compound name
Kinase
Catalog number
16-050
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. CKIa enables protein serine/threonine kinase activity. CK1a is also involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]
Target class
Kinase
Family
Subfamily
Protein Name
CK1α
Protein Alias
CSNK1A1Casein Kinase 1 Alpha 1CKIalphaHLCDGP1PRO2975HEL-S-77p
Accession Number
L37042.1
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C.
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. CKIa enables protein serine/threonine kinase activity. CK1a is also involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]
Target class
Kinase
Family
Accession Number
L37042.1
Target Name
CK1α
Target Alias
CSNK1A1Casein Kinase 1 Alpha 1CKIalphaHLCDGP1PRO2975HEL-S-77p
Origin
Human
Theoretical MW
Affinity Tag
FLAG, 6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
67% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using immuno-affinity chromatography and immobilized metal affinity
chromatography.
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Biological Information
Background
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. CKIa enables protein serine/threonine kinase activity. CK1a is also involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]
Target class
Kinase
Family
Accession Number
L37042.1
Target Name
CK1α
Target Alias
CSNK1A1Casein Kinase 1 Alpha 1CKIalphaHLCDGP1PRO2975HEL-S-77p
Origin
Human
Theoretical MW
Affinity Tag
FLAG, 6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
67% by SDS-PAGE and Coomassie blue staining.
Purification method
Purified using immuno-affinity chromatography and immobilized metal affinity
chromatography.
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only