Aurora A, active Human Recombinant Kinase Protein
N-terminal 6His-tagged recombinant, human full length Aurora A.
No items found.
Biological information
Background
Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.
GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect toGenBank NM_003600. This substitution is reported inGenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given.
Target class
Kinase
Family
AGC
Accession number
NM_003600
Target Name
Aurora A, active Human Recombinant Kinase Protein
Target Alias
AURKA, STK7, AURA, AIK, hARK1, BTAK, AURORA2, aurora-A, Aurora-A, STK15, AurA, ARK1, MGC34538, STK6
Origin
Human
Theori. MW
46.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.
GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect toGenBank NM_003600. This substitution is reported inGenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given.
Compound name
Kinase
Catalog number
14-511
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.
GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect toGenBank NM_003600. This substitution is reported inGenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given.
Target class
Kinase
Family
AGC
Subfamily
Protein Name
Aurora-A
Protein Alias
AURKA, STK7, AURA, AIK, hARK1, BTAK, AURORA2, aurora-A, Aurora-A, STK15, AurA, ARK1, MGC34538, STK6
Accession Number
NM_003600
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.
GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect toGenBank NM_003600. This substitution is reported inGenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given.
Target class
Kinase
Family
AGC
Accession Number
NM_003600
Target Name
Aurora-A
Target Alias
AURKA, STK7, AURA, AIK, hARK1, BTAK, AURORA2, aurora-A, Aurora-A, STK15, AurA, ARK1, MGC34538, STK6
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.
GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect toGenBank NM_003600. This substitution is reported inGenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given.
Target class
Kinase
Family
AGC
Accession Number
NM_003600
Target Name
Aurora-A
Target Alias
AURKA, STK7, AURA, AIK, hARK1, BTAK, AURORA2, aurora-A, Aurora-A, STK15, AurA, ARK1, MGC34538, STK6
Origin
Human
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only