Arg, active Mouse Recombinant Kinase Protein
N-terminal 6His-tagged recombinant, human Arg, amino acids 38-end.
No items found.
Biological information
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict withGenBank XM_136360. These are M982V, reported inGenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported inGenBank U40827. The residue coordinates in the native sequence have been given.
Target class
Kinase
Family
TK
Accession number
NM_005158.2; NM_007314.1
Target Name
Arg, active Mouse Recombinant Kinase Protein
Target Alias
ABL2, Abelson-related, ABLL, ARG
Origin
Mouse
Theori. MW
124.5 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict withGenBank XM_136360. These are M982V, reported inGenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported inGenBank U40827. The residue coordinates in the native sequence have been given.
Compound name
Kinase
Catalog number
14-521
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Kinase Activity Assay Biological information
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict withGenBank XM_136360. These are M982V, reported inGenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported inGenBank U40827. The residue coordinates in the native sequence have been given.
Target class
Kinase
Family
TK
Subfamily
Protein Name
Arg
Protein Alias
ABL2, Abelson-related, ABLL, ARG
Accession Number
NM_005158.2; NM_007314.1
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Mouse
Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
6 months at -70°C
Usage disclaimer
Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict withGenBank XM_136360. These are M982V, reported inGenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported inGenBank U40827. The residue coordinates in the native sequence have been given.
Target class
Kinase
Family
TK
Accession Number
NM_005158.2; NM_007314.1
Target Name
Arg
Target Alias
ABL2, Abelson-related, ABLL, ARG
Origin
Mouse
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Biological Information
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict withGenBank XM_136360. These are M982V, reported inGenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported inGenBank U40827. The residue coordinates in the native sequence have been given.
Target class
Kinase
Family
TK
Accession Number
NM_005158.2; NM_007314.1
Target Name
Arg
Target Alias
ABL2, Abelson-related, ABLL, ARG
Origin
Mouse
Theoretical MW
Affinity Tag
6His
Product Specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only