TrkC Kinase Enzyme Activity Assay Kit
The TrkC Kinase Enzyme Activity Assay Kit offers a validated, ready-to-use biochemical assay based on the renowned ADP Hunter™ Plus Assay platform from DiscoverX for accurately measuring kinase inhibitor efficacy. The kit includes recombinant TrkC, substrate, ATP, detection reagents, and assay plates, enabling precise quantification of ADP accumulation. Designed to handle elevated ATP concentrations, this assay delivers robust, reliable data ideal for high-throughput screening (HTS) and other drug discovery applications.
Biological information
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for TrkC. It comes with all essential components, including recombinant TrkC (Eurofins #14-922), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
TrkC is a receptor tyrosine kinase belonging to the neurotrophin receptor family, specifically activated by neurotrophin-3. The kinase plays key roles in neural development, synapse formation, neuronal survival, and differentiation, particularly in the central and peripheral nervous systems. In drug discovery, TrkC has gained significant attention because chromosomal fusions involving NTRK3 act as potent oncogenic drivers in multiple cancers. These fusions lead to ligand-independent kinase activation and drive tumour proliferation.
Product specifications
Chemical data
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for TrkC. It comes with all essential components, including recombinant TrkC (Eurofins #14-922), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
TrkC is a receptor tyrosine kinase belonging to the neurotrophin receptor family, specifically activated by neurotrophin-3. The kinase plays key roles in neural development, synapse formation, neuronal survival, and differentiation, particularly in the central and peripheral nervous systems. In drug discovery, TrkC has gained significant attention because chromosomal fusions involving NTRK3 act as potent oncogenic drivers in multiple cancers. These fusions lead to ligand-independent kinase activation and drive tumour proliferation.
Product specifications
Kinase Activity Assay Biological information
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for TrkC. It comes with all essential components, including recombinant TrkC (Eurofins #14-922), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
TrkC is a receptor tyrosine kinase belonging to the neurotrophin receptor family, specifically activated by neurotrophin-3. The kinase plays key roles in neural development, synapse formation, neuronal survival, and differentiation, particularly in the central and peripheral nervous systems. In drug discovery, TrkC has gained significant attention because chromosomal fusions involving NTRK3 act as potent oncogenic drivers in multiple cancers. These fusions lead to ligand-independent kinase activation and drive tumour proliferation.
TRKC; GP145-TrkC; gp145(trkC)
Kinase Activity Assay Usage
For Research Use Only
Kinase Activity Assay Information
Biological Information
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for TrkC. It comes with all essential components, including recombinant TrkC (Eurofins #14-922), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
TrkC is a receptor tyrosine kinase belonging to the neurotrophin receptor family, specifically activated by neurotrophin-3. The kinase plays key roles in neural development, synapse formation, neuronal survival, and differentiation, particularly in the central and peripheral nervous systems. In drug discovery, TrkC has gained significant attention because chromosomal fusions involving NTRK3 act as potent oncogenic drivers in multiple cancers. These fusions lead to ligand-independent kinase activation and drive tumour proliferation.
Product Specifications
For Research Use Only
Biological Information
The Kinase Enzyme Activity Assay Kit provides a reliable biochemical method for evaluating kinase inhibitors. Built on HitHunter® assay technology, this kit is specifically optimized for TrkC. It comes with all essential components, including recombinant TrkC (Eurofins #14-922), a substrate, ATP, detection reagents, and assay plates. Each kit is accompanied by a Certificate of Analysis (COA), which outlines the recommended reaction conditions for accurate inhibitor detection. The supplied materials are sufficient to perform experiments covering two, six or twenty five 384-well assay plates.
TrkC is a receptor tyrosine kinase belonging to the neurotrophin receptor family, specifically activated by neurotrophin-3. The kinase plays key roles in neural development, synapse formation, neuronal survival, and differentiation, particularly in the central and peripheral nervous systems. In drug discovery, TrkC has gained significant attention because chromosomal fusions involving NTRK3 act as potent oncogenic drivers in multiple cancers. These fusions lead to ligand-independent kinase activation and drive tumour proliferation.
Product Specifications
For Research Use Only