PRMT1
N-terminal 6His-tagged recombinant, human PRMT1 amino acids 30-371.
Biological information
Background
PRMT1 (Protein arginine methyltransferase 1) is a protein arginine methyltransferase that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the guanidino nitrogen of arginine residues in proteins. PRMT1 specifically targets the omega nitrogen of arginine residues, and catalyzes the formation of asymmetric dimethylarginine (ADMA) residues, which can modulate the structure and function of target proteins. PRMT1 has been shown to play a role in the regulation of gene expression by modulating the function of transcription factors, co-regulators, and RNA polymerase II. PRMT1 has been identified as a potential therapeutic target for various diseases, including cancer and cardiovascular diseases. Its inhibition has been shown to suppress tumor growth and improve heart function in animal models of heart disease.
Target class
Epigenetic
Family
Histone methyltransferase
Accession number
NP_001527.3
Target Name
PRMT1
Target Alias
HMT2, HRMT1L2, IR1B4
Origin
Human
Theori. MW
41.8 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Tris/HCl pH 8.0, 75mM NaCl, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
PRMT1 (Protein arginine methyltransferase 1) is a protein arginine methyltransferase that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the guanidino nitrogen of arginine residues in proteins. PRMT1 specifically targets the omega nitrogen of arginine residues, and catalyzes the formation of asymmetric dimethylarginine (ADMA) residues, which can modulate the structure and function of target proteins. PRMT1 has been shown to play a role in the regulation of gene expression by modulating the function of transcription factors, co-regulators, and RNA polymerase II. PRMT1 has been identified as a potential therapeutic target for various diseases, including cancer and cardiovascular diseases. Its inhibition has been shown to suppress tumor growth and improve heart function in animal models of heart disease.
Compound name
Epigenetic
Catalog number
EPI053
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI053
Datasheet