NSD1
Recombinant human NSD1 amino acids 1810-2120.
Biological information
Background
NSD1 (Nuclear receptor-binding SET domain protein 1) is a histone methyltransferase that belongs to the SET domain-containing protein family. NSD1 specifically targets histone H3 at lysine 36 (H3K36), and catalyzes its mono-, di-, and tri-methylation, leading to changes in chromatin structure and gene expression. NSD1 has been implicated in the regulation of development and growth, including the regulation of body size and brain development. It has also been shown to play a role in the development of several types of cancer, including leukemia and solid tumors. In addition, mutations in the NSD1 gene have been associated with Sotos syndrome, a rare genetic disorder characterized by overgrowth, developmental delay, and intellectual disability. NSD1 is an important epigenetic protein with potential therapeutic applications. Its inhibition has been shown to suppress tumor growth and improve response to chemotherapy in various types of cancer.
Target class
Epigenetic
Family
Accession number
NP_071900.2
Target Name
NSD1
Target Alias
ARA267, KMT3B, SOTOS1
Origin
Human
Theori. MW
35.6 kD
Affinity tag
TEV
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Tris/HCl pH7.5,
125mM NaCl, 1.3mM TCEP, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
NSD1 (Nuclear receptor-binding SET domain protein 1) is a histone methyltransferase that belongs to the SET domain-containing protein family. NSD1 specifically targets histone H3 at lysine 36 (H3K36), and catalyzes its mono-, di-, and tri-methylation, leading to changes in chromatin structure and gene expression. NSD1 has been implicated in the regulation of development and growth, including the regulation of body size and brain development. It has also been shown to play a role in the development of several types of cancer, including leukemia and solid tumors. In addition, mutations in the NSD1 gene have been associated with Sotos syndrome, a rare genetic disorder characterized by overgrowth, developmental delay, and intellectual disability. NSD1 is an important epigenetic protein with potential therapeutic applications. Its inhibition has been shown to suppress tumor growth and improve response to chemotherapy in various types of cancer.
Compound name
Epigenetic
Catalog number
EPI041
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI041
Datasheet