JMJD3
Recombinant, human JMJD3 amino acids 1141-1641.
Biological information
Background
JMJD3 (Jumonji domain-containing protein 3), also known as KDM6B, is a histone demethylase that belongs to the JmjC domain-containing protein family. JMJD3 specifically targets tri-methylated lysine 27 on histone H3 (H3K27me3), and catalyzes its removal, leading to changes in chromatin structure and gene expression. JMJD3 is expressed in a variety of tissues and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD3 has been identified as a potential therapeutic target for various diseases, including cancer, inflammation, and cardiovascular diseases. Its inhibition has been shown to suppress tumor growth and improve response to chemotherapy in various types of cancer. Therefore, JMJD3 is an important epigenetic protein with potential therapeutic applications.
Target class
Epigenetic
Family
Accession number
NP_001073893.1
Target Name
JMJD3
Target Alias
KIAA0346, KDM6B
Origin
Human
Theori. MW
57.2 kDa
Affinity tag
TEV
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Hepes/NaOH pH
7.5, 250mM NaCl, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
JMJD3 (Jumonji domain-containing protein 3), also known as KDM6B, is a histone demethylase that belongs to the JmjC domain-containing protein family. JMJD3 specifically targets tri-methylated lysine 27 on histone H3 (H3K27me3), and catalyzes its removal, leading to changes in chromatin structure and gene expression. JMJD3 is expressed in a variety of tissues and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD3 has been identified as a potential therapeutic target for various diseases, including cancer, inflammation, and cardiovascular diseases. Its inhibition has been shown to suppress tumor growth and improve response to chemotherapy in various types of cancer. Therefore, JMJD3 is an important epigenetic protein with potential therapeutic applications.
Compound name
Epigenetic
Catalog number
EPI034
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI034
Datasheet