JMJD2B
N-terminal 6His-tagged recombinant amino acids 1-363, human JMJD2B.
Biological information
Background
JMJD2B (Jumonji domain-containing protein 2B), also known as KDM4B, is a histone demethylase that belongs to the JmjC domain-containing protein family. It specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2B is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD2B has been shown to play a role in the development of several types of cancer, including breast, prostate, and lung cancers. It has also been implicated in the regulation of various viral infections, including human immunodeficiency virus (HIV) and human papillomavirus (HPV). Therefore, JMJD2B has emerged as a potential target for the development of novel therapeutics for cancer and viral infections.
Target class
Epigenetic
Family
Accession number
NP_055830.1
Target Name
JMJD2B
Target Alias
Origin
Human
Theori. MW
44.3 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Tris/HCl pH 7.5,
250mM NaCl, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
JMJD2B (Jumonji domain-containing protein 2B), also known as KDM4B, is a histone demethylase that belongs to the JmjC domain-containing protein family. It specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2B is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis. JMJD2B has been shown to play a role in the development of several types of cancer, including breast, prostate, and lung cancers. It has also been implicated in the regulation of various viral infections, including human immunodeficiency virus (HIV) and human papillomavirus (HPV). Therefore, JMJD2B has emerged as a potential target for the development of novel therapeutics for cancer and viral infections.
Compound name
Epigenetic
Catalog number
EPI030
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI030
Datasheet