PTPN22, active
N-terminal GST-tagged recombinant, human PTPN22 amino acids 1-312.
No items found.
Biological information
Background
PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) is a member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. This protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease.
GenBank NM_015967
Target class
Phosphatase
Family
Accession number
NM_015967
Target Name
PTPN22, active
Target Alias
Origin
Human
Theori. MW
63.3 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Purity 98% by SDS-PAGE and Coomassie blue staining.
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) is a member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. This protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease.
GenBank NM_015967
Compound name
Phosphatase
Catalog number
14-768
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Lipid Kinase Activity Assay Biological information
Background
PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) is a member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. This protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease.
GenBank NM_015967
Target class
Phosphatase
Family
Subfamily
Protein Name
PTPN22
Protein Alias
Accession Number
NM_015967
UniProt Number
Gene Name
Gene ID
Gene Aliases
Target Species
Human
Lipid Kinase Activity Assay Usage
Product Type
Application
Storage Conditions
1 year at -70°C.
Usage disclaimer
Lipid Kinase Activity Assay Information
Assay Type
Assay Measures
Biological Information
Background
PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) is a member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. This protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease.
GenBank NM_015967
Target class
Phosphatase
Family
Accession Number
NM_015967
Target Name
PTPN22
Target Alias
Origin
Human
Theoretical MW
Affinity Tag
GST
Product Specifications
Expression system
Expressed in E. coli
Purity
Purity 98% by SDS-PAGE and Coomassie blue staining.
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Biological Information
Background
PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) is a member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. This protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease.
GenBank NM_015967
Target class
Phosphatase
Family
Accession Number
NM_015967
Target Name
PTPN22
Target Alias
Origin
Human
Theoretical MW
Affinity Tag
GST
Product Specifications
Expression system
Expressed in E. coli
Purity
Purity 98% by SDS-PAGE and Coomassie blue staining.
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only