Radiation-inducible immediate-early gene IEX-1
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
PDB Code:
Native
Stable
Pure
Active protein
Recombinant protein
Human Origin
Entry name:
IEX1_HUMAN
Gene name:
IER3
Uniprot accession:
P46695
Origin:
Homo sapiens (Human)
Protein family:
IER3
Full-length:
156
Mass:
16903
Sequence:
MCHSRSCHPTMTILQAPTPAPSTIPGPRRGSGPEIFTFDPLPEPAAAPAGRPSASRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILMAEEGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQQHPAAF
