Sodium channel subunit beta-2
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
PDB Code:
Native
Stable
Pure
Active protein
Recombinant protein
Human Origin
Entry name:
SCN2B_HUMAN
Gene name:
SCN2B
Uniprot accession:
O60939
Origin:
Homo sapiens (Human)
Protein family:
Sodium channel auxiliary subunit SCN2B (TC 8.A.17)
Full-length:
215
Mass:
24326
Sequence:
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK