Guided entry of tail-anchored proteins factor 1
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG.
PDB Code:
Native
Stable
Pure
Active protein
Recombinant protein
Human Origin
Entry Name:
GET1_HUMAN
Gene Name:
GET1
Uniprot Accession:
O00258
Origin:
Homo sapiens (Human)
Protein family:
WRB/GET1
Full-length:
174
Mass:
19780
Sequence:
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS