Modulator of macroautophagy TMEM150B
Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner. May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival.
PDB Code:
Native
Stable
Pure
Active protein
Recombinant protein
Human Origin
Entry Name:
T150B_HUMAN
Gene Name:
TMEM150B
Uniprot Accession:
A6NC51
Origin:
Homo sapiens (Human)
Protein family:
DRAM/TMEM150
Full-length:
233
Mass:
25701
Sequence:
MWGYLSLMPVFLAVWAISGVWIVFAIAVTNRTVDLSKGFPYISICGSFPPQSCIFSQVLNMGAALAAWICIVRYHQLRDWGVRRWPNQLILWTGLLCALGTSVVGNFQEKNQRPTHLAGAFLAFILGNVYFWLQLLLWRLKRLPQPGAAWIGPLRLGLCSVCTILIVAMIVLHACSLRSVSAACEWVVAMLLFALFGLLAVDFSALESCTLCVQPWPSLSPPPASPISLPVQL