Services

Membrane protein services

CALIXAR provides both purified membrane proteins that are off the shelf ready for use as well as membrane protein extraction kits to clients to work with the highest quality membrane proteins on the market.

Membrane protein production services

CALIXAR develops and implements full-length membrane proteins while maintaining their structural and functional integrity.

Expression

CALIXAR's native membrane protein expression service increases the success of producing reliable targets or antigens by adapting the expression conditions for each specific target.

See expressions services

Isolation

CALIXAR's membrane protein isolation service extracts native, wild-type, unmutated and untruncated targets so that pharmaceutical companies can produce antibodies and/or discovering primary leads.

See isolation services

Design your project

‍Expression systems: bacteria, yeast, insect cells, HEK & CHO mammalian cells.
Purified formats: detergents, SMALPs, nanodiscs, proteoliposomes.

Design your project

Membrane protein analysis services

CALIXAR will be your unique contact and can deal with all your projects based on membrane proteins. We propose biochemical assays and characterization services to understand the mechanism and interaction of your target.

Ligand binding assays

CALIXAR’s ligand binding assays services provide key information on ligand interactions with any membrane protein targets.

See ligand binding assays

Thermal stability assays

CALIXAR's Thermal Stability Assays provides information on expression levels, stability and ligand binding of membrane proteins.

See thermal stability assays

Identification

CALIXAR provides proteomic and deorphanization services at any stage. We maintain protein-protein and protein-ligand interactions in a native environment.

See identification services

CALIXAR fits your membrane protein services needs

CALIXAR has been successfully supporting membrane protein research from our customers for over a decade now. Membrane proteins are one of the most challenging drug targets to produce and purify, because of their strong bond with the lipid bilayer, involving electrostaticity, hydrogen, and other types of binding. These proteins can vary in size from small peptides to large membrane-bound enzymes, with many different biochemical properties that often require optimization before high scale expression.

Membrane proteins play key roles in life processes, which is why they are attractive targets for drug discovery projects. They can be membrane-bound receptors such as GPCRs, ion channels, transporters, enzymes, or others. Membrane protein-based pharmaceuticals represent more than 60% of all commercialized pharmaceutical drugs including anti-infectives (antibiotics, antivirals,…), cardiovascular therapies (lipid regulators, anticoagulants,…), neurological medicines (pain killers, antiepileptics), and more.

CALIXAR’s membrane protein services include membrane protein expression, solubilization, purification & characterization among others. We also offer membrane protein services to support customers in early research phases (up to Pre-Clinical), or for companies who may be looking for a contract research organization (CRO), or Membrane Protein service providers to supplement their own Membrane Protein capabilities.