Membrane protein ion channel targets

Present in the membranes of all living cells, ion channels are pore-forming proteins that ensure the flow of charged ions from one side of a membrane to the other.

Currently, the second largest target for existing drugs after GPCRs are ion channels, which represent promising targets for the development of additional, novel therapeutic agents in the near future.

CALIXAR’s technology, which provides fully native ion channels for successful drug discovery programs, will contribute to this expansion.

CALIXAR’s integral membrane proteins are produced in their native physiological oligomeric state and in a thermostable form. As their functional and structural integrities are preserved, the purified ion channels may be useful for biological assays and structural-based drug developments.

CALIXAR’s fully native ion channels are intended for all researchers involved in life science: pharmaceutical & biotech companies as well as academic groups.

Our Ion Channel Targets are most suited for these types of life science projects:

• Drug Discovery
• Antibody Discovery
• Vaccine Discovery
• Immunoassays

Full-length and wild-type ion channel proteins developed by CALIXAR are valuable for multiple applications such as small and large molecules screening, antibody development by immunization, and structural biology studies.

Ion channels are often large membrane proteins that may assemble in multimeric forms. The instability of the proteins or complexes can limit biological and structural developments.

Thanks to our patented molecules, CALIXAR’s ion channels are thermostable and functional.

CALIXAR provides our clients with the highest quality membrane ion channel proteins isolated in solution. CALIXAR’s ion channels are full-length, wild-type, pure, functional, and compatible with High Throughput Screening, immunizations, and structural studies by cryo-EM or X-Ray crystallography.