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Soft proprietary detergents

ODG Reagent

CALIXAR’s ODG reagent is a non-ionic amphiphilic detergent / surfactant with a diglucose polar group and an octyl chain.
€ 198.00 (100mg)
€ 363.00 (250mg)
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Information

IUPAC name: N-(2-methyl-1,3-bis(O-β-D-Glucose)propan-2-yl)-3-(octylthio)propanamide

Compound name: ODG

Catalogue number: ODG_100MG
ODG_250MG
ODG_500MG
ODG_1G

Molec. Formula: C27H51NO13S

CAS: nd

MW: 629.8 g/mol

pKa: na​

Percent Composition: C, 51.49; H, 8.16; N, 2.22; O, 33.03; S, 5.09

Production

Physical state: White powder

Purity (HPLC, 214nm): ≥95%

Retention time (RP18 HPLC)b: tR = 12.9 min

CMC: >10 mM

Exact mass: 629.3081

Stability: Store in <-20°C freezer out of direct light

Solubility Structure: Soluble in water (0.5M), methanol and DMSO.

What makes us special

We use a novel & tailored approach to give you an edge

CALIXAR’s ODG is manufactured in a powder form and is used in aqueous solution or buffer. ODG can be processed with biological materials (biological membranes).

Our clients are able to use ODG to help produce lipid detergents, mixed micelles, and protein detergent micelles. ODG allows clients to extract, to solubilize and to stabilize native and functional membrane proteins in solution.

CALIXAR’s ODG is very mild detergent to extract, to solubilize and to stabilize native membrane proteins and is non-ionic. Accordingly, it is not sensitive to ionic concentration or pH fluctuations which is excellent to extract, to solubilize and to stabilize specific membrane proteins.

Our ODG can extract, solubilize and stabilize more efficiently delicate membrane proteins of high medical relevance.

Application note
Native Full-Length Proteins

CALIXAR’s ODG is non-ionic and therefore is not receptive to ionic strength or pH variations and could be well adapted to extract, to solubilize and to stabilize specific membrane proteins.

Specifically made for Biotech

CLAIXAR’s ODG extract high-quality membrane proteins used for research, drug discovery including structural studies and are adapted for use in pharmaceutical, biotechnology companies, as well as for academic teams (biochemists, structural biologists, pharmacologists, virologists) that are involved in the life science fields.

For any Life Science Project
  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage
More documentation

References

ACS PUBLICATIONS

Hydrogenated Diglucose Detergents for Membrane-Protein Extraction and Stabilization

Guillet P. et al. 2019
Read more
Conformational antibody development
Vaccine development
Ligand high-throughput screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets
Conformational antibody development
Vaccine development
High-throughput ligand screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets

Secure and boost
your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins.

Contact us