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DLAC Reagent

CALIXAR’s DLAC reagent is a non-ionic detergent / surfactant with a lactobionamide head group and a decyl chain.
€ 198.00 (250mg)
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Information

IUPAC name: N-decylamine lactobionamide

Compound name: N-decylamine lactobionamide (DLAC)

Catalogue number: DLAC _250MG
DLAC_ 500MG
DLAC_1G

Molec. Formula: C22H43NO11

CAS: nd

MW: 497.6 g/mol

pKa: na​

Percent Composition: C, 53.1; H, 8.71; N, 2.81; O, 35.37

Production

Physical state: White powder

Purity (HPLC, 214nm): 97%

Retention time (RP18 HPLC)b: R = 10.6 min

CMC: 1.3 mM

Exact mass: 497.2836

Stability: Store in <-20°C out of direct light

Solubility Structure: Soluble in water (>100 mM), methanol and DMSO

What makes us special

We use a unique & custom-established procedure to give us the edge

CALIXAR’s DLAC is provided to clients in a powder form and is used in aqueous solutions or buffers. DLAC can be processed with biological materials (biological membranes).

Our clients are able to use DLAC to better produce lipid detergents, mixed micelles, and protein detergent micelles. DLAC provides our clients with a way to extract, to solubilize and to stabilize native and functional membrane proteins.

DLAC is a quite mild detergent to extract, to solubilize and to stabilize native membrane proteins. As DLAC is non-ionic. Therefore, it is not sensitive to ionic strength or pH variations which is ideal to extract, to solubilize and to stabilize specific membrane proteins of high medical relevance.

Application note
Proprietary mild detergent

CALIXAR’s DLAC is non-ionic and therefore not susceptible to ionic strength or pH variations. It is specifically built to extract, solubilize and stabilize precise membrane proteins.

Specifically made for Biotech

CALIXAR’s DLAC (N-decylamine lactobionamide) extracts high-quality membrane proteins utilized for research, drug discovery projects and structural studies. They are used by pharmaceutical firms, biotechnology companies, and academic teams (biochemists, structural biologists, pharmacologists, virologists) that are committed to the life science disciplines.

For any Life Science Project
  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage
More documentation

References

ACS PUBLICATIONS

Lactobionamide Surfactants with Hydrogenated, Perfluorinated or Hemifluorinated Tails

Lebaupain F. et al. 2006
Read more
Conformational antibody development
Vaccine development
Ligand high-throughput screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets
Conformational antibody development
Vaccine development
High-throughput ligand screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets

Secure and boost
your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins.

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