CALXGLUK Reagent
IUPAC Name: 5,11,17-tris{2-[4-(β-D-glucopyranosyl)-1H-1,2,3-triazol-1-yl]ethyl}-25-monoheptoxy-26,27,28-trimethoxycalix[4]arene
Compound name: CALXGLUK
Catalogue number: CALXGLUK_10MG,
CALXGLUK_50MG,
CALXGLUK_100MG
Molec. Formula: C71H95N9O22
CAS: nd
MW: 1426.5 g/mol
pKa: na
Percent Composition: C, 59.78; H, 6.71; N, 8.84; O, 24.67
Physical state: Beige powder
Purity (HPLC, 214nm): <95%
Retention time (RP18 HPLC)b: tR = 13.4 min
CMC: 2.5 mM
Exact mass: 1425.6592
Stability: Store in <-20°C freezer out of direct light
Solubility Structure: Soluble in water (2.5mM), methanol and DMSO
We practice a sole & custom-made approach to give you the edge
CALIXAR’s CALXGLUK is a very gentle detergent used to stabilize native membrane proteins. CALXGLUK is non-ionic and hence is not sensitive to ionic strength or pH fluctuations is well adapted to stabilize many different specific membrane proteins.
Calixar’s CALXGLUK can help deliver lipids-detergents mixed micelles and protein detergent micelles. CALXGLUK also provides for the stabilization of native and functional membrane proteins within a solution.
Our CALXGLUK is provided in a powder form and is used in an aqueous solution or buffer which can also be mixed within biological substances (biological membranes).
CALXGLUK is a non-ionic calixarene based detergent / surfactant with three polar glucose groups and a heptyl chain.
Proprietary mild detergent
CALIXAR’s CALXGLUK is non-ionic and therefore is not sensitive to ionic strength or pH variations and is able to stabilize specific membrane proteins. Due to the fluorinated chain, CALXGLUK does not solubilize lipid membranes.
Specifically made for Biotech
CALIXAR’s CALXGLUK is a high-quality detergent / reagent utilized for research, drug discovery projects, and structural studies. Our technology is adapted for use in pharmaceutical and biotechnology companies, as well as for life science academic teams (biochemists, structural biologists, pharmacologists, virologists).
For any Life Science Project
- Antibodies (including nanobodies, scaffold proteins, aptamers)
- Small molecules
- 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
- Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
- Antibody discovery (Immunization and display technologies)
- Clinical stage (drug validation on reliable native DDLAC)
References
Synthesis of amphiphilic calixarene glycoside detergents and use of same for extracting and stabilizing native functional membrane proteins
