PDB Code:
Home
Products
CALXGLUK
Soft proprietary stabilization reagents

CALXGLUK Reagent

CALIXAR’s CALXGLUK is a calixarene detergent that can be used to solubilize membrane protein as GPCR.
€ 495.00 (10mg)
€ 1,320.00 (50mg)
€ 2,090.00 (100mg)
Request a quoteDownload datasheetDownload MSDS
Information

IUPAC Name: 5,11,17-tris{2-[4-(β-D-glucopyranosyl)-1H-1,2,3-triazol-1-yl]ethyl}-25-monoheptoxy-26,27,28-trimethoxycalix[4]arene

Compound name: CALXGLUK

Catalogue number: CALXGLUK_10MG,
CALXGLUK_50MG,
CALXGLUK_100MG

Molec. Formula: C71H95N9O22

CAS: nd

MW: 1426.5 g/mol

pKa: na

Percent Composition: C, 59.78; H, 6.71; N, 8.84; O, 24.67

Production

Physical state: Beige powder

Purity (HPLC, 214nm): <95%

Retention time (RP18 HPLC)b: tR = 13.4 min

CMC: 2.5 mM

Exact mass: 1425.6592

Stability: Store in <-20°C freezer out of direct light

Solubility Structure: Soluble in water (2.5mM), methanol and DMSO

What makes us special

We practice a sole & custom-made approach to give you the edge

CALIXAR’s CALXGLUK is a very gentle detergent used to stabilize native membrane proteins. CALXGLUK is non-ionic and hence is not sensitive to ionic strength or pH fluctuations is well adapted to stabilize many different specific membrane proteins.

Calixar’s CALXGLUK can help deliver lipid detergent mixed micelles and protein detergent micelles. CALXGLUK also provides for the stabilization of native and functional membrane proteins within a solution.

Our CALXGLUK is provided in a powder form and is used in an aqueous solution or buffer which can also be mixed within biological substances (biological membranes).

CALXGLUK is a non-ionic calixarene based detergent / surfactant with three polar glucose groups and a heptyl chain.

Application note
Native Full-Length Proteins

CALIXAR’s CALXGLUK is non-ionic and therefore is not sensitive to ionic strength or pH variations and is able to stabilize specific membrane proteins. Due to the fluorinated chain, CALXGLUK does not solubilize lipid membranes.

Specifically made for Biotech

CALIXAR’s CALXGLUK is a high-quality detergent / reagent utilized for research, drug discovery projects, and structural studies. Our technology is adapted for use in pharmaceutical and biotechnology companies, as well as for life science ​academic teams (biochemists, structural biologists, pharmacologists, virologists).

For any Life Science Project
  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage (drug validation on reliable native DDLAC)
More documentation

References

PROPRIETARY PATENT

Synthesis of amphiphilic calixarene glycoside detergents and use of same for extracting and stabilizing native functional membrane proteins

Dauvergne J. 2015
Read more
Conformational antibody development
Vaccine development
Ligand high-throughput screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets
Conformational antibody development
Vaccine development
High-throughput ligand screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets

Secure and boost
your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins.

Contact us