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CALX8
Soft proprietary detergents

CALX8 Reagent

CALIXAR’s CALX8 reagent is a calixarene based detergent/surfactant with three polar carboxylic groups and a octyl chain.
€ 1,320.00 (50mg)
€ 2,090.00 (100mg)
€ 3,300.00 (250mg)
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Information

5,11,17-tris[(carboxy)methyl]-25-monooctyloxy-26,27,28-trihydroxycalix[4]arene

Compound name: CALX8

‍Catalogue number: CALX8_50MG, CALX8_100MG, CALX8_250MG

‍Molec. Formula: C42H43Na3O10

‍CAS: nd

‍MW: 776.7 g/mol p

Ka: na​

‍Percent Composition: C, 64.94; H, 5.58; N, 8.88; O, 20.60

Production

Physical state: Beige powder

Purity (HPLC, 214nm): nd

Retention time (RP18 HPLC): nd

CMC: 0.85 mM

Exact mass: 776.2549

Stability: Store in <-20°C out of direct light

Solubility Structure: Soluble in methanol, DMSO and water

What makes us special

We employ a unique & custom-made procedure to award us the edge

The Calixarene platform and carboxylic groups help to stabilize native membrane proteins and the alkyl chain serves to extract native membrane proteins at the same time.

CALIXAR’s CALX8 is in powder form and is used in an aqueous solution or buffer. CALX8 can be combined with biological materials (such as biological membranes).

Our clients are able to use CALX8 to assist in the development of lipids-detergents mixed micelles, and protein detergent micelles. CALX8 enables clients to extract, solubilize and stabilize native and functional membrane proteins in a solution.

CALX8 is very mild detergent to secure, to solubilize and to preserve native membrane proteins which is ideal for extraction, to solubilization and to stabilization of particular membrane proteins.

Application note
Proprietary mild detergent

CALIXAR’s CALX8 is adapted to extract, to solubilize or to stabilize precise membrane proteins.

Specifically made for Biotech

CALIXAR’s CALX8 extracts high-quality membrane proteins that are utilized for pharmaceutical research, discovery and, structural studies. Our CALX8 is used by biotechnology companies, as well as for academic teams (biochemists, structural biologists, pharmacologists, virologists) that are involved in the life science fields.

For any Life Science Project
  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage
More documentation

References

ANALYTICAL BIOCHEMISTRY

Novel systematic detergent screening method for membrane proteins solubilization

Desuzinges Mandon E. et al. 2017
Read more
JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxisomal ATP-binding cassette transporters form mainly tetramers

Flore Geillon et al. 2017
Read more
Conformational antibody development
Vaccine development
Ligand high-throughput screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets
Conformational antibody development
Vaccine development
High-throughput ligand screening
Structure-based drug discovery
Immunoassays
Deorphanization projects
Identification of relevant targets
Expression of full-length membrane proteins
Functional isolation and stabilization of targets

Secure and boost
your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins.

Contact us