The Calixarene platform and carboxylic groups help to stabilize native membrane proteins and the alkyl chain serves to extract native membrane proteins at the same time.
CALIXAR’s CALX8 is in powder form and is used in an aqueous solution or buffer. CALX8 can be combined with biological materials (such as biological membranes).
Our clients are able to use CALX8 to assist in the development of lipids-detergents mixed micelles, and protein detergent micelles. CALX8 enables clients to extract, solubilize and stabilize native and functional membrane proteins in a solution.
CALX8 is very mild detergent to secure, to solubilize and to preserve native membrane proteins which is ideal for extraction, to solubilization and to stabilization of particular membrane proteins.
- Antibodies (including nanobodies, scaffold proteins, aptamers)
- Small molecules
- 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
- Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
- Antibody discovery (Immunization and display technologies)
- Clinical stage