CALIXAR’s membrane protein solubilization, stabilization, and purification techniques require reagents (detergents and surfactants). CALIXAR’s proprietary reagents were developed specifically to meet the unique challenge of membrane proteins. They have been proven to be efficient in more than 170 projects in the production of functional and native membrane proteins.
With our reagent expertise, we have developed membrane protein extraction kits, including soft proprietary detergents and stabilization additives. Our kits enable you to extract, stabilize or purify native membrane complexes from cells using standard laboratory equipment found in all laboratories. Thus, providing you with high-quality membrane proteins for your discovery projects.
Our proprietary detergents and reagents are supplied in powder form which can be directly dissolved in water or organic solvents and provide the following benefits:
- Improved membrane protein stability, allowing them to be isolated at higher concentrations than is normally possible with other surfactants.
- Obtain non-denatured proteins for better drug discovery and clinical achievements.
- Enhanced binding affinity between target proteins and antibodies allowing more sensitive immunoassays.
Some of our membrane protein reagents are also effective as subcellular fractionation agents, enabling the production of new native antigens to be used, for example, to make inactivated vaccines.